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Active ingredient of drug Celecoxib

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Celebrex is a synthetic drug whose main component is celecoxib. It is a nonsteroidal anti-inflammatory analgesic that removes the enzyme cyclooxygenase and ensures the conversion of arachidonic acid to prostaglandins. It is a powerful medicine and should be used with caution.

General information about Celebrex

It is a synthetic drug that is representative of coxibs and belongs to the group of nonsteroidal anti-inflammatory drugs. The effect of the drug, along with the action of other members of the nonsteroidal anti-inflammatory drug group, is to remove the enzyme cyclooxygenase, which converts arachidonic acid into prostaglandins. One of the pharmacological properties of celecoxib is that it is the first representative of the selective inhibitors of the Cox-2 COX isoform, which is produced exclusively in inflammatory foci.

Other drugs previously considered to be selective COX-2 inhibitors, namely meloxicam, nimesulide, etodolac and nabumetone, are currently considered to be the preferred COX-2 inhibitors. that is, their selectivity to COX-2 is lower than that of coxibs.

This is the lack of effect on COX-1 when celecoxib is used to significantly reduce the risk of serious side effects of the digestive system, and the lack of the antiplatelet effect of celecoxib in turn causes an increased risk of side effects of the cardiovascular system. and some studies suggest that, like other coxibs, the risk of cardiovascular complications may increase by 37% (though not all researchers agree). This drug has a pronounced analgesic effect, comparable to the effects of other non-narcotic analgesics and some narcotic analgesics (so-called "soft"), and can be used for postoperative analgesia in small operations (especially dental).

The drug also reduces cytokine production, reduces metalloproteinase activity, reduces chondrocyte apoptosis, and neoangiogenesis. In addition, it inhibits angiogenesis and induces apoptosis of tumor cells and can be used to reduce the risk of colon cancer, even in familial polyposis of the colon. Studies on the use of this medicine in the treatment of Alzheimer's disease and amyotrophic lateral sclerosis have been conducted, but its use in these diseases has been ineffective.

However, the experimental use of the drug against schizophrenia, bipolar affective disorders and depressive disorders has a positive effect as it affects the degenerative processes of the nervous system associated with inflammatory processes. One of the disadvantages of Celebrex is its low ability to dissolve in water. The product is therefore used exclusively orally. Although the effect on the premature closure of the ductus arterialis is not proven, it is not recommended during pregnancy.

Celebrex precautions

The tablets are contraindicated in hypersensitivity and other non-steroidal anti-inflammatory drugs, aggravation of gastric ulcers and duodenal ulcers, gastrointestinal bleeding, bleeding disorders and liver failure, and renal and bronchial asthma with concomitant nasal polyposis and persistent chromosis. Impermeability, insufficiency and diagnosed coronary artery disease, vascular obliteration of the lower extremities, pregnancy and lactation in the cortex; Children under 18 years.

Celebrex dosage

In adults with osteoarthritis, pills are prescribed in a daily dose of 200 mg in one or two doses. You can increase the dose to 400 mg / day. In rheumatoid arthritis, the drug is prescribed in a daily dose of 200-400 mg, divided into 2 doses. In some cases, the dose may be increased to 800 mg / day.

For chronic pain syndrome, the recommended single dose is 100-200 mg. If necessary, further use of the pills in the same dose is possible for at least 4 to 6 hours between doses up to a maximum daily dose of 400 mg.

For acute pain and Aldgodimenorrhoe the recommended starting dose is 400 mg. If necessary, an additional dose of the drug in a dose of 200 mg is possible. The maximum dose on the first day of treatment is 600 mg / day.

In the following days, the daily dose may vary from 200 mg to 400 mg.

In the treatment of familial adenomatous intestinal polyposis, the drug is prescribed for endoscopic or surgical treatment of polyposis over a prolonged period in a single dose of 100 mg / day.

In patients with moderate hepatic impairment doses should be reduced by 50%.

How to take Celebrex?

In the treatment of acute pain syndromes on an empty stomach, in other cases after eating, use orally. If the patient has missed the time of the next dose, the missed dose should be taken as soon as possible with the next dose taken as before. You should not double the next dose if you forget to take it.

Side effects of Celebrex

The characteristic consequences of using Celebrex as a generic and other medicines in the Coxibs group are the side effects of the cardiovascular system. Although the drug, unlike the other drug group Coxibe - Rofecoxib, affects blood pressure and other cardiovascular parameters, the incidence of cardiovascular complications may be 37%, according to clinical studies, if the use of celecoxib. Among the side effects of the cardiovascular system, blood pressure instability, peripheral edema, progression of heart failure, tachycardia and arrhythmia are more frequently observed. rare myocardial infarction, stroke, cardiovascular death.

When this drug is used, the digestive system causes fewer side effects than most other nonsteroidal anti-inflammatory drugs. Most commonly on the part of the digestive system (more than 1% of cases) the following side effects are observed: abdominal pain, diarrhea, flatulence, nausea, liver dysfunction, vomiting, heartburn; The exacerbations of gastric ulcer, erosive esophagitis, pancreatitis and intestinal perforation are rarely observed (0.01-0.1%). extremely rare is gastrointestinal bleeding, liver failure.

Other side effects can be observed:

  • Skin and allergic reactions - common (more than 1% of cases) rash, itchy skin, coughing; rarely (0.1 to 1%) alopecia, urticaria, shortness of breath, bronchospasm (only long-term use in high doses); Photodermatosis, Stevens-Johnson syndrome, Lyell's syndrome, Quincke's edema, erythema multiforme.
  • Nervous system - common (more than 1%), headache, dizziness, insomnia less often anxiety, drowsiness, tinnitus, taste and sensations of smell; extremely rare hallucinations, confusion, aseptic meningitis.

Changes in laboratory tests - Thrombocytopenia, leukopenia, anemia, and increased liver enzyme activity may occur.

Celebrex overdose

Data on overdose studies are limited. Clinical side effects observed with a single dose of up to 1 milligram and repeated doses of up to 1 milligram per day in 2 doses were not identified.

Treatment: In case of overdose special care treatment is required. Dialysis is not an effective method for elimination of celecoxib from the blood because it has a high level of plasma protein binding.

Interactions with Celebrex

The instructions in each package of the medicinal product indicate that the medicine may behave differently in combination with other medicinal products: the efficacy and duration of exposure may decrease.

Celebrex complex treatment with:

  • Warfarin is associated with an increased risk of bleeding.
  • Fluconazole and ketoconazole - twice as much Celebrex in the blood;
  • With lithium preparations, the lithium concentration in the blood increases by about 17%.

Celebrex and alcohol

Alcohol consumption increases the risk of side effects on the body (especially gastrointestinal bleeding).

Celebrex reviews

Peter: There was an indication of a facet syndrome (infernal pain in the middle of the back, to the right of the spine), I covered it with diclofenac and stains, but after 14 days everything came back, after which I drank these pills for 2 weeks , Everything is gone; the back does not hurt the second year. He is not bad at the pain!

Bredl: I'm 38 years old. I am suffering from a herniated disc. I forgot what life is without pain. I have tried many painkillers. Celebrex was the most effective. I first took a (prescribed by a doctor) loading dose: 2 capsules of 200 mg, then 1 capsule of 200 mg in the morning and 1 capsule of 200 mg in the evening. I'm very happy with the result, the pain is very bearable and easy. I wanted to take a break and stopped drinking capsules, a strong pain came back after two days. I had to drink 2 capsules of 200 mg a day. It's been 3 months since I drink these pills without a break, because of the side effects I have: 1. swollen face in the morning (as if I'm getting drunk at night), it passes in 1-2 hours, 2. There was Confusion (feeling uncontrollable), but I think it's an overdose. That day I drank 3 capsules instead of the usual two. That's all It's not cheap, but more effective than anything I've discovered. This is in no way an advertisement, it is my personal case. During the illness, this means that in the last 2 years, I have often contacted people with the same problem and understood that there is no universal medicine that always helps. Trust your body. Good luck.

Jane: My eyes are very tired working on the computer at the end of the day. I feel red and itch, so I want to close it and not open it. And without a computer, there is no alternative now. I applied many different drops, such as artificial tears, etc. Everything was useless until I tried this drug. After a month of use the eyes reacted much calmer to the computer!

Teodor: I have ankylosing spondylitis. The pain in the joints is constant, sometimes so strong that it is impossible to leave the bed. Of all the painkillers, this pill has become the most effective for me. The price is high, but it's worth it. I drank it before going to bed and slept well all night, and in the morning I almost ran. People with gastric ulcers should be careful because they can get worse. In parallel, drugs must be taken to protect the stomach lining. In general, there are many contraindications. Please read the instructions carefully.


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