Buy Celebrex Singapore
Payment Methods: VISA, Mastercard, American Express, Jcb card, Diners Club
Availability?: In Stock!
Prescription required? No Prescription Required for buy Generic Celebrex
Active ingredient of drug Celecoxib
Medical form: Pills
Shipping: Worldwide shipping: Singapore, Australia, Malaysia...
Delivery time: EMS Trackable (5-9 days), Airmail (10 - 21 days)
Celebrex is a synthetic drug whose main component is celecoxib. It is a nonsteroidal anti-inflammatory analgesic that removes the enzyme cyclooxygenase and ensures the conversion of arachidonic acid to prostaglandins. It is a powerful medicine and should be used with caution.
General information about Celebrex
It is a synthetic drug that is representative of coxibs and belongs to the group of nonsteroidal anti-inflammatory drugs. The effect of the drug, along with the action of other members of the nonsteroidal anti-inflammatory drug group, is to remove the enzyme cyclooxygenase, which converts arachidonic acid into prostaglandins. One of the pharmacological properties of celecoxib is that it is the first representative of the selective inhibitors of the Cox-2 COX isoform, which is produced exclusively in inflammatory foci.
Other drugs previously considered to be selective COX-2 inhibitors, namely meloxicam, nimesulide, etodolac and nabumetone, are currently considered to be the preferred COX-2 inhibitors. that is, their selectivity to COX-2 is lower than that of coxibs.
This is the lack of effect on COX-1 when celecoxib is used to significantly reduce the risk of serious side effects of the digestive system, and the lack of the antiplatelet effect of celecoxib in turn causes an increased risk of side effects of the cardiovascular system. and some studies suggest that, like other coxibs, the risk of cardiovascular complications may increase by 37% (though not all researchers agree). This drug has a pronounced analgesic effect, comparable to the effects of other non-narcotic analgesics and some narcotic analgesics (so-called "soft"), and can be used for postoperative analgesia in small operations (especially dental).
The drug also reduces cytokine production, reduces metalloproteinase activity, reduces chondrocyte apoptosis, and neoangiogenesis. In addition, it inhibits angiogenesis and induces apoptosis of tumor cells and can be used to reduce the risk of colon cancer, even in familial polyposis of the colon. Studies on the use of this medicine in the treatment of Alzheimer's disease and amyotrophic lateral sclerosis have been conducted, but its use in these diseases has been ineffective.
However, the experimental use of the drug against schizophrenia, bipolar affective disorders and depressive disorders has a positive effect as it affects the degenerative processes of the nervous system associated with inflammatory processes. One of the disadvantages of Celebrex is its low ability to dissolve in water. The product is therefore used exclusively orally. Although the effect on the premature closure of the ductus arterialis is not proven, it is not recommended during pregnancy.
The tablets are contraindicated in hypersensitivity and other non-steroidal anti-inflammatory drugs, aggravation of gastric ulcers and duodenal ulcers, gastrointestinal bleeding, bleeding disorders and liver failure, and renal and bronchial asthma with concomitant nasal polyposis and persistent chromosis. Impermeability, insufficiency and diagnosed coronary artery disease, vascular obliteration of the lower extremities, pregnancy and lactation in the cortex; Children under 18 years.
In adults with osteoarthritis, pills are prescribed in a daily dose of 200 mg in one or two doses. You can increase the dose to 400 mg / day. In rheumatoid arthritis, the drug is prescribed in a daily dose of 200-400 mg, divided into 2 doses. In some cases, the dose may be increased to 800 mg / day.
For chronic pain syndrome, the recommended single dose is 100-200 mg. If necessary, further use of the pills in the same dose is possible for at least 4 to 6 hours between doses up to a maximum daily dose of 400 mg.
For acute pain and Aldgodimenorrhoe the recommended starting dose is 400 mg. If necessary, an additional dose of the drug in a dose of 200 mg is possible. The maximum dose on the first day of treatment is 600 mg / day.
In the following days, the daily dose may vary from 200 mg to 400 mg.
In the treatment of familial adenomatous intestinal polyposis, the drug is prescribed for endoscopic or surgical treatment of polyposis over a prolonged period in a single dose of 100 mg / day.
In patients with moderate hepatic impairment doses should be reduced by 50%.
How to take Celebrex?
In the treatment of acute pain syndromes on an empty stomach, in other cases after eating, use orally. If the patient has missed the time of the next dose, the missed dose should be taken as soon as possible with the next dose taken as before. You should not double the next dose if you forget to take it.
Side effects of Celebrex
The characteristic consequences of using Celebrex as a generic and other medicines in the Coxibs group are the side effects of the cardiovascular system. Although the drug, unlike the other drug group Coxibe - Rofecoxib, affects blood pressure and other cardiovascular parameters, the incidence of cardiovascular complications may be 37%, according to clinical studies, if the use of celecoxib. Among the side effects of the cardiovascular system, blood pressure instability, peripheral edema, progression of heart failure, tachycardia and arrhythmia are more frequently observed. rare myocardial infarction, stroke, cardiovascular death.
When this drug is used, the digestive system causes fewer side effects than most other nonsteroidal anti-inflammatory drugs. Most commonly on the part of the digestive system (more than 1% of cases) the following side effects are observed: abdominal pain, diarrhea, flatulence, nausea, liver dysfunction, vomiting, heartburn; The exacerbations of gastric ulcer, erosive esophagitis, pancreatitis and intestinal perforation are rarely observed (0.01-0.1%). extremely rare is gastrointestinal bleeding, liver failure.
Other side effects can be observed:
- Skin and allergic reactions - common (more than 1% of cases) rash, itchy skin, coughing; rarely (0.1 to 1%) alopecia, urticaria, shortness of breath, bronchospasm (only long-term use in high doses); Photodermatosis, Stevens-Johnson syndrome, Lyell's syndrome, Quincke's edema, erythema multiforme.
- Nervous system - common (more than 1%), headache, dizziness, insomnia less often anxiety, drowsiness, tinnitus, taste and sensations of smell; extremely rare hallucinations, confusion, aseptic meningitis.
Changes in laboratory tests - Thrombocytopenia, leukopenia, anemia, and increased liver enzyme activity may occur.
Data on overdose studies are limited. Clinical side effects observed with a single dose of up to 1 milligram and repeated doses of up to 1 milligram per day in 2 doses were not identified.
Treatment: In case of overdose special care treatment is required. Dialysis is not an effective method for elimination of celecoxib from the blood because it has a high level of plasma protein binding.
Interactions with Celebrex
The instructions in each package of the medicinal product indicate that the medicine may behave differently in combination with other medicinal products: the efficacy and duration of exposure may decrease.
Celebrex complex treatment with:
- Warfarin is associated with an increased risk of bleeding.
- Fluconazole and ketoconazole - twice as much Celebrex in the blood;
- With lithium preparations, the lithium concentration in the blood increases by about 17%.
Celebrex and alcohol
Alcohol consumption increases the risk of side effects on the body (especially gastrointestinal bleeding).
Peter: There was an indication of a facet syndrome (infernal pain in the middle of the back, to the right of the spine), I covered it with diclofenac and stains, but after 14 days everything came back, after which I drank these pills for 2 weeks , Everything is gone; the back does not hurt the second year. He is not bad at the pain!
Bredl: I'm 38 years old. I am suffering from a herniated disc. I forgot what life is without pain. I have tried many painkillers. Celebrex was the most effective. I first took a (prescribed by a doctor) loading dose: 2 capsules of 200 mg, then 1 capsule of 200 mg in the morning and 1 capsule of 200 mg in the evening. I'm very happy with the result, the pain is very bearable and easy. I wanted to take a break and stopped drinking capsules, a strong pain came back after two days. I had to drink 2 capsules of 200 mg a day. It's been 3 months since I drink these pills without a break, because of the side effects I have: 1. swollen face in the morning (as if I'm getting drunk at night), it passes in 1-2 hours, 2. There was Confusion (feeling uncontrollable), but I think it's an overdose. That day I drank 3 capsules instead of the usual two. That's all It's not cheap, but more effective than anything I've discovered. This is in no way an advertisement, it is my personal case. During the illness, this means that in the last 2 years, I have often contacted people with the same problem and understood that there is no universal medicine that always helps. Trust your body. Good luck.
Jane: My eyes are very tired working on the computer at the end of the day. I feel red and itch, so I want to close it and not open it. And without a computer, there is no alternative now. I applied many different drops, such as artificial tears, etc. Everything was useless until I tried this drug. After a month of use the eyes reacted much calmer to the computer!
Teodor: I have ankylosing spondylitis. The pain in the joints is constant, sometimes so strong that it is impossible to leave the bed. Of all the painkillers, this pill has become the most effective for me. The price is high, but it's worth it. I drank it before going to bed and slept well all night, and in the morning I almost ran. People with gastric ulcers should be careful because they can get worse. In parallel, drugs must be taken to protect the stomach lining. In general, there are many contraindications. Please read the instructions carefully.
- Alternative arthritis medicine
- Arthritis relief
- Arthritis treatment
- Athletes injuries and liquid glucosamine for joint pain
- Homeopathy and degenerative arthritis
- How high heels are associated with arthritis
- Is it time for a chair lift
- Natural cures for arthritis
- Prescription anti inflammatory could protect against lung cancer
Generic Celebrex 100mg
Generic Celebrex 200mg
Do you want to buy the high-quality drug Celebrex inexpensively in Singapore? Perhaps you are faced with unjustified difficulties and obstacles to the acquisition of this medication.
- Perhaps when you tried to purchase Celebrex before from a pharmacy, you have been asked to present a prescription. Or you did not have the time, desire or the financial means to visit a doctor and they refused to sell it to you.
- You experienced the sale of counterfeit drugs, which did not have any effect and spoiled your mood and self-esteem.
- You are unsure if the active ingredient in the drug Celecoxib can help anyone.
It's not a problem! Our online store vgrsingapore.net offers the sale of certified Celebrex to you without having to search for a prescription! We fulfill orders in Singapore, as well as, ship internationally worldwide! Packages always reach their destination on time, in perfect condition. The amount of drug always complies with the amount stipulated; its action is efffective by its quality.
You absolutely do not need to worry if you do not want the fact of your purchase known by postal workers, or simple passers-by who may examine your parcel. Our store sends packages in a way where orders remain confidential. In other words, you will never find any signs or numbers, or letters, or other markings that would make it clear what kind of content is in the package.
All orders are packed in one-color packaging, indistinguishable from the hundreds and thousands of others at the post office.
We offer our valued customers the opportunity to save on the purchase. If you order a large package of Celebrex, your price would be significantly lower! This is a great opportunity to not spend money unnecessarily. If you want to learn more about all the terms of a potential transaction, we warmly invite you to go over to the section labeled "Savings". For customers who purchase medicines from our store in Singapore specifically for shipping to another country, in the amount of 290 SGD at the current rate, we provide absolute free shipping anywhere in the world, within the time period agreed upon in advance.
You can pay online using our completely secure checkout page on our Singapore store website.
Thus, it eliminates the possibility of data leakage or unauthorized access to information by third parties, and will provide a protective ssl connection which provides 100% protection of your purchase. For payment, you can use any form that is convenient for you: Visa, American Express or Mastercard.
A nice bonus for our valued customers is, our store is open continuously, around the clock, without days off and breaks for the holidays. Therefore, there is always assistance from employees with medical education to serve you: online consultation will help you find answers to any question about buying Celebrex.
We ask you to support the activities of our online store, if you liked our services. Clicking on the icon (g+), you will help our pharmacy very much. For you, too, there will be a little surprise - a special discount of gratitude from our shop.
If you will also recommend our organization to your friends in Singapore, we are also happy to give you a new discount on your Celebrex product.