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Active ingredient of drug Propranolol

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Inderal is a medicine used to treat health problems such as high blood pressure, angina pectoris, tachycardia, including hyperthyroidism, extrasystoles, essential tremor, pheochromocytoma, Graves' Disease and thyroid crisis. In addition, it can be used for the prevention of migraine, alcohol withdrawal.

General information about Inderal

Inderal (active ingredient - propranolol) is a long-standing drug known for the treatment of stenocardia and other heart disease that helps a person overcome various old and acquired phobias.

People with heart disease are very familiar with medicines in which propranolol is an active ingredient. Among other things, it is Inderal. These medicines relieve angina, hypertension and migraine and are used as a prophylactic agent for the prevention of heart attacks.

Propranolol is a beta-blocker that suppresses the release of adrenaline in the blood and thus the development of anxiety and fear. Thus, this drug can now be administered, for example, to reduce post-traumatic stress.

This medicine is designed to help fight the following health problems: essential and renal hypertension, heart angina, cardiac arrhythmia, migraine, anxiety, essential tremor, thyrotoxicosis, obstructive hypertrophic cardiomyopathy, pheochromocytoma (with alpha-adrenergic blockers).

Prolonged treatment with Inderal should be stopped slowly and under medical supervision. Patients who use contact lenses in the eye should be aware that tear fluid production may decrease during treatment with the above. At the same time, the concomitant use of insulin and blood glucose lowering drugs may increase the efficacy of these drugs.

Inderale precautions

Treatment with this product should be under medical supervision. It reduces compensatory cardiovascular reactions in response to the administration of general anesthetics. It should be noted that intravenous use in children is not recommended. In addition, elderly patients are at risk of developing central nervous system side effects.

In case of abnormal liver function it is recommended to reduce the dose of the drug. This agent can mask the signs of glycophenia and rapid heartbeat in diabetics taking insulin and other hypoglycemic drugs. During treatment, it is advisable to exclude alcoholic drinks. People who use motorists and those whose work requires increased attention should take this medicine with particular care. During treatment, test results may change during laboratory tests (eg increased urea content, transaminases, phosphatases).

Hypersensitivity to the drug, cardiogenic shock, asthma spasmodic and history of bronchospasm, metabolic acidosis, peripheral circulatory disorders, bradycardia, AV block, congestive heart failure, Prinzmetal's angina, hypotension, pregnancy, breastfeeding.

This medicine can not be used in the following conditions:

  • Cardiac conduction disorders (blockade)
  • Heart rate below 55 beats per minute
  • Low blood pressure
  • heart failure
  • Raynaud's disease and other vascular diseases that block blood flow
  • bronchial asthma
  • a depression.

Inderale dosage

For diagnosed hypertension, a dose of 40 mg twice daily is usually prescribed; In case of insufficient expression of antihypertensive effect, the dose should be increased 3 times daily to 40 mg or 2 times daily to 80 mg. General recommendation that the maximum daily dose should not exceed 320mg.

For diagnosed angina pectoris or cardiac arrhythmia, the initial dose of the drug is usually 20 mg three times a day. It can then be gradually increased to 80 mg 2 to 3 times a day. In this case, the maximum daily dose is 240 mg. When using the prolonged form of this product (depot capsules: 0.08 g), the frequency of taking the medication is 1 time per day.

To prevent migraine and essential tremor, the starting dose of the drug is 40 mg 2 to 3 times daily. If necessary, the dosage can be gradually increased up to 160 mg per day.

In the case of paroxysmal heart rate and thyroid seizure treatment, this drug may be slowly administered intravenously in an amount of 1 mg (1 ml of a 0.1% solution). then in 2 minutes it can be repeated in the same dosage.

If intravenous administration has no effect, treatment should be repeated until the maximum dose of 10 mg is reached. All these manipulations may only be performed under arterial pressure and under ECG control.

How to take Inderal?

This medicine may be taken orally 10 to 3 times a day 15 to 30 minutes before meals, followed by a gradual increase in the dose to 20-40 mg 3 to 4 times a day (sometimes) up to 320 to 480 mg / day). , To stop (alleviate) cardiac arrhythmias, the 1 mg dose is first administered intravenously. Depending on the effect and tolerability, the dose can then be increased to 5 times. 10 mg.

With caution, the drug should be prescribed to pregnant and lactating women and patients with liver failure, kidney disease and diabetes. Pregnant women taking propranolol should discontinue 48 to 72 hours before delivery. it is necessary to constantly check the condition of the newborn. Patients with pheochromocytoma can only prescribe the drug after taking an alpha-blocker. Stopping a longer treatment should be done gradually under medical supervision.

Inderale side effects

The use of Inderal can cause the following side effects:

  • Cardiovascular system and blood (hematopoiesis, hemostasis): slowing of the heart rate, heart failure, AV block, hypotension, impairment of peripheral circulation, thrombocytopenia, leukopenia, agranulocytosis.
  • Nervous system and sensory organs: fatigue, dizziness, headache, insomnia, drowsiness, nightmares, mental reactions and reduced motor, emotional lability, depression, restlessness, hallucinations, confusion in time and space, short-term amnesia, sensitivity weakened, paresthesia; dry eyes, blurred vision, keratoconjunctivitis.
  • Gastrointestinal tract: illness, vomiting, abdominal pain, stomach pain or constipation, mesenteric artery thrombosis, ischemic colitis.
  • Respiratory system: pharyngitis, stethia, cough, dyspnoea, bronchospasm and laryngism, respiratory distress syndrome.
  • Skin: alopecia, rash, itching, aggravation of psoriasis.
  • Other: withdrawal syndrome, decreased libido, impotence, Peyronie's disease, arthralgia, allergic reactions, lupus syndrome, hypoglycemia, fever.

Overdose with Inderal

The following symptoms of overdose include dizziness, bradycardia, arrhythmia, heart failure, hypotension, collapse, difficulty breathing, acrocyanosis, seizures. Treatment: gastric lavage and formulation of adsorbents, symptomatic treatment: atropine, beta-adrenomimetics (isoprenaline, izadrin), sedatives (diazepam, lorazepam), cardiotonic (dobutamine, dopamine, epinephrine), vasopressors, glucagon, etc. transvenous stimulation is possible. Hemodialysis is ineffective in this case.


Taking other medicines or supplements with you may increase the efficacy of Inderal. The patient is obliged to inform the doctor about the intake of medicines, vitamins and supplements. With this information, the doctor can follow the appropriate treatment, avoiding negative interactions.

Inderal can interact with the following drugs and products:

  1. Amiodarone
  2. Ammitriptyline
  3. Aspirin
  4. Clomipramine
  5. diclofenac
  6. Doxazosin
  7. Warfarin

Propranolol increases (for both sides), the negative effects of verapamil and diltiazem on the myocardium prolongs the action of non-depolarizing muscle relaxants and inhibits the elimination of lidocaine. Heparin, antacids lower the plasma levels of this drug and cimetidine and phenothiazines - increase. Concomitant use of monoamine oxidase inhibitors is not recommended. It slows down the metabolism of theophylline and increases its concentration in the blood plasma.

Interaction of alcohol with Inderal

Ethyl alcohol, which is a constituent of alcoholic beverages, can interact with drugs both at the point of distribution in the body and during metabolism (transformation). Such effects may weaken or intensify the action of the drugs and cause the development of undesirable side effects which may be extremely severe.

The compatibility of this substance with alcohol is very low. Their simultaneous use is dangerous. Reviews of some parents of patients show that the consequences of concomitant use of propranolol and alcohol are fatal. This indicates an extremely high risk to take this drug after drinking alcohol. First, this combination can cause blood pressure to drop to an extremely low level. The medical definition of such a condition is an orthostatic collapse. The state manifests itself in a strong pressure drop, for example when getting up. As a rule, such a condition is accompanied by nausea, chills, weakness, limb cooling and lack of coordination.

The more alcohol the patient drinks, the lower the blood pressure. In addition, alcohol can dramatically increase the side effects of taking the medicine. There may be hypotension or even weakness.

Hypotension is accompanied by headache and dizziness, nausea, drowsiness and so on. When propranolol is prescribed for the treatment of high blood pressure or tachycardia, its effectiveness is reduced to nothing if the person consumes alcohol during the treatment.

During treatment with propranolol, alcohol consumption must be avoided, even at minimal doses. This can affect the work of almost all internal organs and body systems.

It is therefore dangerous to underestimate the possible consequences of the concomitant use of this medicine and alcohol, as this could have fatal consequences. It must be remembered that the magnitude of the harmful effects of alcohol on the body is so great that it is almost impossible to predict all the consequences of such a combination.

Inderal reviews

The returns are mostly positive. Users and physicians report that drug treatment is often effective. In addition, many are satisfied with the low price of medication. Inderal maintains blood pressure at a normal level and quickly eliminates palpitations. The drug reduces the manifestations of heart disease, relieves a person of restlessness.

Jan: I have high blood pressure. I have been taking pills for a long time. I was prescribed different pills.

Not so long ago, the doctor decided to prescribe a drug containing propranolol. It was Inderal. I have been using it for six months. So far there are no problems, the result is good.

Helena: I had heart problems. The doctor prescribed Inderal. When I started to use this substance, I felt like in my youth, the pressure and pulse are normal.


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