Buy Nolvadex Singapore
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Active ingredient of drug Tamoxifen
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Nolvadex (Tamoxifen) is an anti-neoplastic antineoplastic treatment for breast cancer. This is a hormone therapy, this medicine is classified as "anti-estrogen".
General informations about Nolvadex
Breast cancer is the most common type of tumor in women in Europe, America and some Asian countries. Each year, more than one million cases of this disease are registered worldwide and with an average life expectancy of 80 years, the risk of developing breast cancer is 12.5%. Over the last 20 years, the incidence of this cancer has increased steadily worldwide and in Russia, especially in cities and megacities. At 31.2%, it has been the number one cancer disease in women since 1985. It is known that annual control contributes to the early detection of tumors. However, patients often consult a doctor who already has obvious signs of a tumor, making subsequent treatment difficult.
One of the reasons for this is the lack of understanding of the importance of early diagnosis of the disease. Today, scientists are deeply involved in the mechanisms of cancer cell formation, although much remains to be clarified. Breast cancer, like other cancers, is insidious and aggressive. Therefore, it is very important that every human being has an idea of the origin of this disease: A warned man is armed.
Breast cancer also occurs in men. These cases are diagnosed 100 times less often than in women, but even in this case, the disease is often fatal and needs to be treated. The causes of breast tumors in men include a rare mutation in BRCA2 susceptibility, obesity and hormonal disorders. Unlike benign growth of breast tissue, malignant degeneration requires immediate treatment.
The treatment of breast cancer is based on a complex approach combined with surgical treatment. The tumor is affected by drugs, radiation, hormones, including target therapy, which involves ingestion of a drug that blocks the work of certain genes only in the tumor cells and slows the growth of the neoplasm.
Tamoxifen citrate (generic Nolvadex) was synthesized in 1962. Originally, it was used only for certain forms of treatment of female infertility. Clinical studies have shown that this drug is not ideal for female infertility. Tamoxifen is the key ingredient in Nolvadex, a nonsteroidal substance with anti-estrogenic properties.
The drug is indicated for the adjunctive treatment of breast neoplasia in women (menopause) with affected lymph nodes and metastatic breast cancer in men and women. It is also used to treat ovarian cancer, uterine cancer, clear cell carcinoma, neocarcinoma, adult soft tissue sarcoma in the presence of estrogen receptors in neoplasm and treatment. prostate cancer resistant to chemotherapy.
It must be said that Nolvadex is neither an androgen nor anabolic and can therefore be used in bodybuilding to develop muscles. In this sport, it is used simultaneously with anabolic steroids, which can have the following side effects:
- excessive accumulation of water in the body,
- Increased fat mass,
- Increased mammary glands in humans.
For this reason, Nolvadex is prescribed to prevent the occurrence of these effects. It must be said that this drug is taken by athletes during a diet because it promotes the burning of fat. The effect of the remedy is to increase the muscle density of bodybuilders.
When using tamoxifen, existing contraindications must be taken into account. The absolute contraindications for women are:
- an allergic reaction to components of the drug
- Pregnancy and breast feeding;
- Young age.
The other contraindications are:
- Disorders of rheological properties of blood;
- Thrombophlebitis and varicose veins of the extremities or pelvic organs due to the risk of exacerbations;
- severe liver disease, bile and hepatitis;
- Disorders of the visual organs;
- Disorders of the lipid profile of the blood;
- increase in calcium concentration;
- impaired absorption and metabolism of lactose.
This medication is prohibited to men with excessive sensitivity to the components. Take special care with this medicine in men with diabetes mellitus. In case of kidney disease, tamoxifen is also contraindicated. In thromboembolic disorders, the use of this drug is not recommended.
DOSAGE OF TAMOXIFES
- The dosage of this drug is almost identical for men and women with cancer.
- Before taking the medication, read the instructions and recommendations carefully.
- Usually, the drug is taken in the form of a tablet twice a day. After one week, this dose is doubled (ie two tablets twice a day). The duration of treatment depends on the course of the disease and the results of the treatment.
- The minimum course duration is one to three months.
Regarding athletes taking Nolvadex, here are some other recommendations. Athletes use this drug primarily during post-course treatment after using anabolic steroids to restore their own testosterone levels. The dose of Nolvadex administered to steroids for the second to third week is 0.01 to 0.02 g per day. After the end of steroid treatment, the drug is continued within 2-3 weeks.
The tamoxifen-containing agent is used to treat very complex and severe forms of hormonal disorders and oncological diseases. The drug is prescribed exclusively for adults.
The product should only be washed with water in large quantities. It is recommended to divide the daily dose into two doses - morning and evening, regardless of the meal.
Side effects of tamoxifen
Taking this medicine may have the following side effects:
- paroxysmal heat sensations (heat waves);
- Vaginal discharge or bleeding;
- Itching in the genital area;
- Hair loss (complete loss is rare);
- Pain in the region of neoplasms;
- Pain in the bones;
- Weight gain.
- Water retention;
- decreased appetite
- Sizchasia and vomiting;
- the constipation;
- increased fatigue
- loss of consciousness;
- increase in body temperature;
- Vision disorders (including changes in keratoderma, cataracts and retinal degeneration);
- retrobulbar neuritis;
- transient decrease in leukocyte and platelet counts;
- transient elevation of liver enzymes (ALT and AST);
- Infiltration of fatty liver, cholestasis (biliary obstruction), hepatitis.
In addition, side effects such as:
- Risk of blood clots and thromboembolism;
- proliferation of the endometrium and increased risk of uterine cancer;
- The pain in the bones at the beginning of the treatment disappears later;
- The end of the menstrual cycle or irregular menstruation in premenopausal women;
- Appearance of ovarian cystic tumors.
When using this medication, athletes may experience side effects such as:
- increase in body temperature;
- partial hair loss;
- Nausea, dry mouth, marked reduction of erection;
- very fast fatigue;
- temporary constipation.
As there are no studies on overdose cases with Nolvadex, it can be assumed that overdose may result in the undesirable effects described above. Treatment should be symptomatic in this case because there is no specific antidote.
INTERACTIONS of Nolvadex
Do not combine with hormonal medications, especially estrogen. Co-administration of drugs acting on the blood coagulation system requires adjustment of the Nolvadex dosage. In combination with cytostatics, the risk of thrombosis increases. Combinations with progestins are fine.
TAMOXIFES and ALCOHOL
Of course, many people are aware of the harmful effects of alcohol on the body. Therefore, it is recommended to take most non-alcoholic medications.
In some cases, however, compatibility of the alcohol and the tamoxifen-containing agent is possible. However, this permission should be given by the doctor himself. The reason is the peculiarities of the human body and its predisposition to certain diseases. The combined use of alcohol and products containing tamoxifen is only possible with the approval of the attending physician.
Each drug, as well as alcohol, has an irritating effect on the mucous membranes of the digestive organs. Therefore, taking agents containing tamoxifen with alcohol will put more stress on the digestive system. Such a combination is particularly terrible for people with diseases of the digestive system. Based on the evidence provided, it is recommended to reduce alcohol consumption while taking Nolvadex. In this way, the drug will more effectively affect the diseased organs and the new organism will not contract new diseases.
Below you will find comments from athletes and patients taking tamoxifen medicines.
Marina, 27 years old: In 2015, 2nd grade breast cancer was diagnosed. After the breast removal operation and after radiotherapy, the doctor prescribed Nolvadex (tamoxifen). I take it for 2.5 years, the disease is not progressing.
Felix, 29 years old (bodybuilder): Nolvadex (tamoxifen) is doing well with his work on estrogen suppression. But I had time to feel the side effects. Headaches and blurred vision occur at regular intervals.
Debera, 39 years old: I have been taking a medicine containing tamoxifen since 2014, since I was diagnosed with a malignant neoplasm. After the operation, histological examination revealed that the tumor was hormone-dependent. In this context, I was prescribed a daily intake of this medication.
I go to the gynecologist every three months. I had no side effects except for the tides. Sudden hot flashes - the condition is quite bearable and the disadvantages of everyday life are not expressed.
Merry, 48: For me, it's a high quality and very effective medicine. Yes, it has many side effects and contraindications, but it helps me. Of course, it all depends on the degree of the tumor, but if the doctor recommends you take this medicine, there is still a reason to take it.
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